Basic Information
VIS ID
TVIS20001451
Fusion event
HPV-CUBN integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
17132405/17090406 (Hg38)
End
17132405/17090406 (Hg38)
Location type
Intronic
Target gene
CUBN
miRNAs that regulate target gene
hsa-mir-5590-5p ; hsa-mir-607 ; hsa-mir-130b-5p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3973 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-3135b ; hsa-mir-140-5p ; hsa-mir-4760-3p
Nearest miRNA
hsa-mir-1265/Upstream/2653745; hsa-mir-107/Downstream/754701;
Nearest TSS
ENST00000439456/Upstream/106211; ENST00000497849/Downstream/37431;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/272430, chr10-CpG: 49/Downstream/110899
Upstream sequence
GGCACACTTCTGCCCTTGGATTTTATACCCCAGTATCCTCAAAATTCTCATTTTGTTCAAGTTAATGAGCATTGGGTACTTTTATCACTTGTGACCAAGA
Downstream sequence
ATTCTAACTAATatgagaaactgaggcttagtggtttagtggttacaacccaggaccagcattgccatctgtgaatagtagagtcaggattcaaacccag
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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