Basic Information
VIS ID
TVIS20001454
Fusion event
HPV-CCNY integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr10
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
35662775/35373847 (Hg38)
End
35662775/35373847 (Hg38)
Location type
Intronic
Target gene
CCNY
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-let-7b-5p ; hsa-mir-744-5p ; hsa-mir-93-3p ; hsa-mir-193b-3p ; hsa-mir-4669 ; hsa-mir-6516-5p ; hsa-mir-6751-5p ; hsa-mir-6803-5p ; hsa-mir-455-3p ; hsa-mir-4497 ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-6499-3p ; hsa-mir-6835-5p ; hsa-mir-1233-3p ; hsa-mir-1225-3p ; hsa-mir-4795-5p ; hsa-mir-1296-3p ; hsa-mir-298 ; hsa-mir-4696 ; hsa-mir-1252-5p ; hsa-mir-186-3p ; hsa-mir-922 ; hsa-mir-4733-5p ; hsa-mir-3613-3p
Nearest miRNA
hsa-mir-1265/Upstream/294167; hsa-mir-107/Downstream/267325;
Nearest TSS
ENST00000439456/Upstream/36795; ENST00000470025/Downstream/60264;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/36235, chr10-CpG: 75/Downstream/233743
Upstream sequence
TTCATACCTCAGAGAGCATAATAGTAATAAGGTAATAAAACAAAGCAGGATCATCACCACTAATAACCTGAGAGGGAAGTCCTGCTAAGACTTCATCTCT
Downstream sequence
ATCACGGAATATTCTTGGTCATTACTTAGATGGGAGCGTTTCCCACATCACATCTCTAATTCAGTAATTGCTTTTCGTGTGCGtgagacaaggtctcgtt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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