Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene499939645099089152298350511167375111950451109139511111895110602151106810511295515112987351146157
Basic Information
VIS ID
TVIS20001458
Fusion event
HPV-PRKG1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr10
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
52905917/51146157 (Hg38)
End
52905917/51146157 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
PRKG1
miRNAs that regulate target gene
hsa-mir-20a-5p ; hsa-mir-218-5p ; hsa-mir-3591-5p ; hsa-mir-1273e ; hsa-mir-921 ; hsa-mir-3606-5p
Nearest miRNA
hsa-mir-1265/Upstream/2160570; hsa-mir-107/Downstream/153416;
Nearest TSS
ENST00000439456/Upstream/71587; ENST00000645790/Downstream/99649;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/71165, chr10-CpG: 40/Downstream/553334
Upstream sequence
CGTCTATGTCCATTTGAACTTCCCCTAACCTCCCACACCCTCACTCAGATTAGGTGTGTCCTCTTCCTCCATCTAAAAGCATTCCTTTACAGTCATCCAT
Downstream sequence
TCTGCCATTGACATCAAAATTTCCTTTTTCTTGAAAAAAAAAATCCTTCCTCTTTATTCATTGTCCTTTACTATAACTCAAACTCCCATGCTTGTTGTTT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate