Basic Information
VIS ID
TVIS20001460
Fusion event
HPV-PCDH15 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr10
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
56856238/55096478 (Hg38)
End
56856238/55096478 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
PCDH15
Nearest miRNA
hsa-mir-1265/Upstream/488521; hsa-mir-107/Downstream/2208001;
Nearest TSS
ENST00000439456/Upstream/295187; ENST00000453639/Downstream/223136;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2224812, chr10-CpG: 36/Downstream/531830
Upstream sequence
AGTACTAGGCATTCTGTGGTTTTTACTAAGTGCAAATGCCTTCCCTCAAGTAGAGGACCTCTGTAGGCTGGGCTTGCTCAGCCAGGAATTCACCTTGGGA
Downstream sequence
TTCTGAAGATATGTATAGCTTCGCTGTTTGTGGATTTCACATTTATGAGCCCTTCCTTGGCACTTGTCATAACTGTCCGTTAAAAGTTTGCATTTTTCCC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate