Basic Information
VIS ID
TVIS20001463
Fusion event
HPV-LOC105378314 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr10
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
59601497/57841737 (Hg38)
End
59601497/57841737 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
LOC105378314
Nearest miRNA
hsa-mir-1265/Upstream/537178; hsa-mir-107/Downstream/5531220;
Nearest TSS
ENST00000439456/Upstream/1480462; ENST00000489785/Downstream/426197;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/1480223, chr10-CpG: 34/Downstream/264884
Upstream sequence
GGGGCAGGTGTGAAATGCCCCACGAGTGCAGAAGTCCCTCAGGCAGAGGTTTCCTCCTCTGAGAGCCCTTGCCCATCTCCCGTGCTGCTGCAGTGACTGG
Downstream sequence
GAGGCAGCTGTGGCTGTTGGACCCAGACAGGCTGGAGAAAGGAGAGGATGTCGCCCCCAAAGCCCTCGTGCGCCTGGGCTGTGGGAAGCCTGATTGCTTT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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