Basic Information
VIS ID
TVIS20001471
Fusion event
HPV-CASC2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Host Sequence
Chromosome
chr10
Cytoband
q26.11
Reference genome
End
119853114/118093603 (Hg38)
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-107/Upstream/925829; hsa-mir-202/Downstream/1284369;
Nearest cancer related gene
CASC2(TSG, No orient, 0)
Upstream sequence
gaatatagtatatacatatacaaaatatgtattaattgtgttataggtaagggttgcagtcaacaggaggctattagttaagtttttggggagtcaaaag
Downstream sequence
ttacacacagattttcaactccatgaaggggttgtttctcctaacccctgagttgttcaaagatcagctgTATTAACTTGTTTTCTCAAGTGCCCCATAC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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