Basic Information
VIS ID
TVIS20001475
Fusion event
HPV-EDRF1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr10
Cytoband
q26.13
Reference genome
GRCh37/hg19
Start
127410417/125721848 (Hg38)
End
127410417/125721848 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
EDRF1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-30d-5p ; hsa-mir-21-5p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p
Nearest miRNA
hsa-mir-107/Upstream/688978; hsa-mir-202/Downstream/97892;
Nearest TSS
ENST00000439456/Upstream/2145; ENST00000530795/Downstream/3918;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/1851, chr10-CpG: 68/Downstream/51813
Upstream sequence
aggtgcctgcagccccagctactttggaggctgaggcaggagaatggcatgaacccgggaggcggagcttgcagtgagtccagatcacaccactgcactc
Downstream sequence
cagcctgggtgacagaacaagactctgtctcaaaaaaaaaaaagaaaaaaatgtagtcccttttctctgcatcctctctagcattttgttattttttgtc
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate