Basic Information
VIS ID
TVIS20001477
Fusion event
HPV-NAV2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
19510854/19489307 (Hg38)
End
19510854/19489307 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
NAV2
miRNAs that regulate target gene
hsa-mir-663a ; hsa-mir-98-5p ; hsa-mir-16-5p ; hsa-mir-6825-5p ; hsa-mir-7106-5p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-3202 ; hsa-mir-3179 ; hsa-mir-6876-5p ; hsa-mir-4779 ; hsa-mir-4476 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6835-3p ; hsa-mir-4668-5p ; hsa-mir-1298-5p ; hsa-mir-664a-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6759-5p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-2117 ; hsa-mir-6793-5p ; hsa-mir-6748-5p ; hsa-mir-597-3p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-299-3p ; hsa-mir-6818-3p ; hsa-mir-6888-3p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-3120-5p ; hsa-mir-335-3p ; hsa-mir-664b-3p ; hsa-mir-5696 ; hsa-mir-579-3p ; hsa-mir-627-3p
Nearest miRNA
hsa-mir-210/Upstream/1101447; hsa-let-7a-2/Downstream/86003;
Nearest TSS
ENST00000527297/Upstream/138583; ENST00000534229/Downstream/16593;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/142620, chr11-CpG: 140/Downstream/223083
Upstream sequence
aagcaatctgcagattcaatgcaattcctatcaaactgccaatgtcatttttcacaaaattagaaagaaactattccaaaattcaaacaaaacaaaaaaa
Downstream sequence
gacacgaaatagtcaaagcaatcctaagtaataagaacaaagctggaggcatcacattacctgacttcaaaccatactacaagatcgcaataaccaaaac
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate