Basic Information
VIS ID
TVIS20001480
Fusion event
HPV-AMBRA1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr11
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
46505999/46484449 (Hg38)
End
46505999/46484449 (Hg38)
Location type
Intronic
Target gene
AMBRA1
miRNAs that regulate target gene
hsa-mir-339-5p ; hsa-mir-331-3p ; hsa-mir-186-5p ; hsa-mir-1231 ; hsa-mir-1299 ; hsa-mir-1343-3p ; hsa-mir-208a-3p ; hsa-mir-208b-3p ; hsa-mir-23a-5p ; hsa-mir-23b-5p ; hsa-mir-24-3p ; hsa-mir-3202 ; hsa-mir-3689d ; hsa-mir-3928-5p ; hsa-mir-3929 ; hsa-mir-4419b ; hsa-mir-4478 ; hsa-mir-4533 ; hsa-mir-485-5p ; hsa-mir-555 ; hsa-mir-571 ; hsa-mir-6128 ; hsa-mir-6134 ; hsa-mir-6515-5p ; hsa-mir-6758-5p ; hsa-mir-6776-5p ; hsa-mir-6783-3p ; hsa-mir-6796-3p ; hsa-mir-6806-3p ; hsa-mir-6851-5p ; hsa-mir-6856-5p ; hsa-mir-6861-5p ; hsa-mir-6881-5p ; hsa-mir-6884-5p ; hsa-mir-759 ; hsa-mir-875-3p
Nearest miRNA
hsa-mir-129-2/Upstream/32560; hsa-let-7a-2/Downstream/268676;
Nearest TSS
ENST00000527297/Upstream/66454; ENST00000579280/Downstream/9444;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/91312, chr11-CpG: 45/Downstream/109198
Upstream sequence
cacacagatatataaagcaaatattattaaagcaaaagagaaaggtagatctcaagataataataacttgtgacttctacaccccactgtcagcattgga
Downstream sequence
cagatcgcctagacagaaaatcaacaaggaaacatcagactttatctgcactatagagcaaattgacctaatagatatttacaggacatttcatccagta
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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