Basic Information
VIS ID
TVIS20001491
Fusion event
HPV-ZBTB16 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr11
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
113935839/114065117 (Hg38)
End
113935839/114065117 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA11G
Target gene
ZBTB16
miRNAs that regulate target gene
hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-5580-3p ; hsa-mir-190a-3p ; hsa-mir-301b-3p ; hsa-mir-3145-3p ; hsa-mir-186-3p ; hsa-mir-5685 ; hsa-mir-4699-3p ; hsa-mir-4690-3p ; hsa-mir-3908 ; hsa-mir-330-3p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-15a-5p ; hsa-mir-6838-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-6749-3p ; hsa-mir-452-3p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-4469 ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-5088-3p ; hsa-mir-5193 ; hsa-mir-1470 ; hsa-mir-4667-3p ; hsa-mir-1306-5p ; hsa-mir-5011-5p ; hsa-mir-6778-3p ; hsa-mir-3162-3p ; hsa-mir-361-3p ; hsa-mir-6849-3p
Nearest miRNA
hsa-mir-10392/Upstream/615029; hsa-let-7a-2/Downstream/4578883;
Nearest TSS
ENST00000527297/Upstream/705; ENST00000545851/Downstream/115649;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/3649, chr11-CpG: 18/Downstream/17781
Nearest cancer related gene
ZBTB16(TSG, No orient, 0)
Upstream sequence
AGATCATAACCTCTGAAAGGACATTCTGTTGACAAAGCATGTGTGTTCTGTAGGGTATCTTATCCACTGCTGAACAAGTGGTACAATTATCACATCCTAC
Downstream sequence
TTTTGGCCCATTCCAGAAGCAGGAAGAATGCTATTGAATTACAGTTAATATTCTGAAAGCATAAATTTCAAATTGGTCTTCTGGCTACAATTGGGGGAGA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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