Basic Information
VIS ID
TVIS20001508
Fusion event
HPV-MYRFL integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr12
Cytoband
q15
Reference genome
GRCh37/hg19
Start
70299376/69905596 (Hg38)
End
70299376/69905596 (Hg38)
Location type
Intronic
Target gene
MYRFL
Nearest miRNA
hsa-let-7i/Upstream/320773; hsa-mir-1178/Downstream/9513661;
Nearest TSS
ENST00000382841/Upstream/80280; ENST00000299350/Downstream/20979;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/165817, chr12-CpG: 102/Downstream/337241
Upstream sequence
cttcacagctccagctataacctttatttgaggactcccaaatttgaatctgtaatctttcatttgcagagaaaatgctgcaactgtgcatcctcaccca
Downstream sequence
ggtatcctaatggaccagcacctgcaaggtttccaaactgaatttctgatcttccctacaaaatcaactacttttcttctgtttctcaatagaccacctt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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