Basic Information
VIS ID
TVIS20001510
Fusion event
HPV-MGAT4C integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr12
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
86920287/86526510 (Hg38)
End
86920287/86526510 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
MGAT4C
miRNAs that regulate target gene
hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-5584-5p ; hsa-mir-607 ; hsa-mir-1277-5p ; hsa-mir-496 ; hsa-mir-656-3p ; hsa-mir-410-3p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-4666a-5p ; hsa-mir-5011-5p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-4789-3p ; hsa-mir-4719 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-4797-5p ; hsa-mir-8485 ; hsa-mir-377-3p ; hsa-mir-3614-3p ; hsa-mir-1287-3p
Nearest miRNA
hsa-let-7i/Upstream/5368049; hsa-mir-1178/Downstream/218558;
Nearest TSS
ENST00000382841/Upstream/270096; ENST00000551280/Downstream/74794;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1245588, chr12-CpG: 52/Downstream/1508818
Upstream sequence
cattgtttctccaagattggtctctagtgacttatttagttcatttggtgaggtcatgtttttctggatggtcttgatgtttgtggatgtttgtctgtgt
Downstream sequence
ccaggcattgaagagttaggtatttattgcagtcttctcagtctggccttcttcgtattcttccttttttgggaaggctttccaagtattcaaaaggact
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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