Basic Information
VIS ID
TVIS20001515
Fusion event
HPV-WSCD2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr12
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
108543302/108149525 (Hg38)
End
108543302/108149525 (Hg38)
Location type
Intronic
Target gene
WSCD2
miRNAs that regulate target gene
hsa-mir-4496 ; hsa-mir-4704-5p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-6818-3p ; hsa-mir-6873-3p ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-3941 ; hsa-mir-6755-3p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-570-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-758-3p ; hsa-mir-3611 ; hsa-mir-367-5p ; hsa-mir-1267
Nearest miRNA
hsa-let-7i/Upstream/3557809; hsa-mir-1178/Downstream/486285;
Nearest TSS
ENST00000382841/Upstream/17744; ENST00000546811/Downstream/39821;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/19829, chr12-CpG: 66/Downstream/365400
Upstream sequence
ATATGAACAAGCAGTTACCTTTTAATCAAGATTAAAAATTCTAAGTTGttaggttggtgcaagagtaattgcagtgtttgccattaaaagtaattactgg
Downstream sequence
tgcatcaacctGtattttatttaaaatgtaatataagccatttaaaatattaatataaacatatttaaaGCTACAATGTTACAAAGGAtgagattttaga
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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