Basic Information
VIS ID
TVIS20001521
Fusion event
HPV-POLE integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
133252225/132675639 (Hg38)
End
133252225/132675639 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
POLE
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-324-5p ; hsa-mir-222-3p ; hsa-mir-93-5p ; hsa-mir-92a-3p ; hsa-mir-10b-3p ; hsa-mir-2115-5p ; hsa-mir-3925-3p ; hsa-mir-4790-5p ; hsa-mir-488-5p ; hsa-mir-515-5p ; hsa-mir-519e-5p ; hsa-mir-544b ; hsa-mir-597-3p ; hsa-mir-665 ; hsa-mir-6804-5p ; hsa-mir-766-3p
Nearest miRNA
hsa-let-7i/Upstream/93578;
Nearest TSS
ENST00000382841/Upstream/1998; ENST00000454379/Downstream/859;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1982, chr12-CpG: 272/Downstream/11237
Upstream sequence
aagggaactcccctttataaaaccatcagatctcgttagacttattcactgtcacgagaacagcacggtaaggatccgtccccatgattcaattgcctcc
Downstream sequence
tactgggtccctcccacaacatgtggggactatgggaactacaattcagctgagattggagtgggacacagccatatcatatcaGTCATCTAAAcagaag
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate