Basic Information
VIS ID
TVIS20001555
Fusion event
HPV-GOLGA8M integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr15
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
28974948/28729802 (Hg38)
End
28974948/28729802 (Hg38)
Location type
Intronic
Target gene
GOLGA8M
miRNAs that regulate target gene
hsa-mir-620 ; hsa-mir-4531 ; hsa-mir-1270 ; hsa-mir-4325 ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-4424 ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u
Nearest miRNA
hsa-mir-1268a/Upstream/238957; hsa-mir-10393/Downstream/2335230;
Nearest TSS
ENST00000557528/Upstream/17479; ENST00000559709/Downstream/8582;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/140116, chr15-CpG: 118/Downstream/7721
Upstream sequence
ATGCACACACACAACTCATGGTGCCAATTCCACTTTAAGAAACTCATATTGAATAAGACAAAGCACTCAACAAAGTACCTGACATCATACATTGTCTCAC
Downstream sequence
AGAGCATGTATATTATGCAAAAGCAGCCTGAAATATTTTATTCACAGATAGACAGACAATGCTTGACTCCCTGCTAATCTGAAATACTTCATGGGGAGGG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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