Basic Information
VIS ID
TVIS20001562
Fusion event
HPV-GNB5 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr15
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
52467434/52175237 (Hg38)
End
52467434/52175237 (Hg38)
Location type
Intronic
Target gene
GNB5
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-128-3p ; hsa-mir-148a-3p ; hsa-mir-27a-3p ; hsa-mir-26b-5p ; hsa-mir-425-5p ; hsa-mir-6807-5p ; hsa-mir-1292-3p ; hsa-mir-4279 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-4722-3p ; hsa-mir-6727-3p ; hsa-mir-6877-3p ; hsa-mir-6819-3p ; hsa-mir-5089-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6778-3p ; hsa-mir-4707-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-150-5p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-186-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-512-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p
Nearest miRNA
hsa-mir-10393/Upstream/861128; hsa-mir-11181/Downstream/101880;
Nearest TSS
ENST00000557528/Upstream/30776; ENST00000559779/Downstream/4650;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/62456, chr15-CpG: 100/Downstream/4146
Upstream sequence
aaagaaagaaataaaagaaccagccaggcacagtggctcatgccttaatctcggcactttggtgggggttaagacaggagagtgcttgaggccaggagtt
Downstream sequence
ATGTTGCTCTGGGGAATAAACCATACCCCTCTGGTGTCAGCCGCATACCCTAATTTGGTACTATAAAACTCATGTGTCTGGCCACACATTCCCAATTCAC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate