Basic Information
VIS ID
TVIS20001568
Fusion event
HPV-FBXO22 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr15
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
76210576/75918235 (Hg38)
End
76210576/75918235 (Hg38)
Location type
Intronic
Target gene
FBXO22
miRNAs that regulate target gene
hsa-mir-106b-5p ; hsa-mir-1-3p ; hsa-mir-3671 ; hsa-mir-95-5p ; hsa-mir-5692c ; hsa-mir-5692b
Nearest miRNA
hsa-mir-10393/Upstream/155920; hsa-mir-11181/Downstream/3291553;
Nearest TSS
ENST00000557528/Upstream/4967; ENST00000564220/Downstream/14565;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/13626, chr15-CpG: 105/Downstream/141108
Upstream sequence
GGAGAATTTGGCTTCTCCAGAAGCTTCTGTCAAGGCACCCACCAGGGAAGTCACCCAGTCTAGAAGTGAGGAGCTCCCTGGAACCCCAGAAGCCAGTCTT
Downstream sequence
CAAAGGTAAAATTTGTTTTACTGATGAGGAAAAAAAGGGGGTATACACATTGAGACTAGTTTTTACAACTATCCCTGACAATGTGGAAAAAAAAAAAAAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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