Basic Information
VIS ID
TVIS20001610
Fusion event
HPV-TBX4 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr17
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
59538198/61460837 (Hg38)
End
59538198/61460837 (Hg38)
Location type
Intronic
Target gene
TBX4
miRNAs that regulate target gene
hsa-mir-181a-5p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-142-3p ; hsa-mir-6073 ; hsa-mir-20b-3p ; hsa-mir-3137 ; hsa-mir-5011-5p ; hsa-mir-648 ; hsa-mir-6505-5p ; hsa-mir-3941 ; hsa-mir-6128 ; hsa-mir-6757-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-578 ; hsa-mir-7152-5p ; hsa-mir-4724-3p ; hsa-mir-3667-3p ; hsa-mir-1914-5p ; hsa-mir-4789-5p
Nearest miRNA
hsa-mir-10226/Upstream/1417732; hsa-mir-1250/Downstream/1483378;
Nearest TSS
ENST00000595228/Upstream/4373; ENST00000593249/Downstream/2547;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/2944, chr17-CpG: 43/Downstream/1164
Upstream sequence
GACGTCTTGGGCTGTACCGCACTTGTTGGGCCCTCCGCCACCCACCCCAGGCTCAAGAATGCAAACACCACTCAGAAGGATATGAATTCTGACAAGAGCG
Downstream sequence
TTCATAGCCTGTTGAGTTCAATGTTGCTTGTGTTAGTGACAGTGAATTTGCGTTTGAAAAATGAACTACCGATGAGAACTCCTGTTGAACCTGTATTGTT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate