Basic Information
VIS ID
TVIS20001629
Fusion event
HPV-ZNF560 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
9598555/9487879 (Hg38)
End
9598555/9487879 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ZNF560
miRNAs that regulate target gene
hsa-mir-1273h-5p ; hsa-mir-149-3p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-203b-3p ; hsa-mir-2467-3p ; hsa-mir-30b-3p ; hsa-mir-30c-1-3p ; hsa-mir-30c-2-3p ; hsa-mir-3612 ; hsa-mir-3689a-3p ; hsa-mir-3689b-3p ; hsa-mir-3689c ; hsa-mir-377-5p ; hsa-mir-4257 ; hsa-mir-455-3p ; hsa-mir-4728-5p ; hsa-mir-5694 ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-6785-5p ; hsa-mir-6788-5p ; hsa-mir-6799-5p ; hsa-mir-6807-5p ; hsa-mir-6883-5p ; hsa-mir-7106-5p ; hsa-mir-7158-3p ; hsa-mir-887-5p ; hsa-mir-25-5p ; hsa-mir-4537 ; hsa-mir-658
Nearest miRNA
hsa-mir-1227/Upstream/1098499; hsa-let-7e/Downstream/550475;
Nearest TSS
ENST00000633603/Upstream/17987; ENST00000589751/Downstream/10728;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/52253, chr19-CpG: 39/Downstream/10249
Upstream sequence
TGACCTTCCTGCCAGCCGTCTCTGCTGGTCAGGTTGACCTCCTGACACCATCCCCAACTGTGTGACCCATCAGCTGGCCATCTCTGCTCAGCCACACGAC
Downstream sequence
aagaatgacaatatggaacctggaacgaagacatctggttggatccagataagaaacatgatcttaaaccccactatgatttggatgtggtctgtcccca
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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