Basic Information
VIS ID
TVIS20001632
Fusion event
HPV-ELAVL3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
11562833/11452018 (Hg38)
End
11562833/11452018 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ELAVL3
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-6510-5p ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-25-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-658 ; hsa-mir-185-5p ; hsa-mir-5699-5p ; hsa-mir-1225-3p ; hsa-mir-4323 ; hsa-mir-3141 ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6773-5p ; hsa-mir-6724-5p ; hsa-mir-6071 ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-296-5p ; hsa-mir-6882-3p ; hsa-mir-942-5p ; hsa-mir-3692-5p ; hsa-mir-93-3p ; hsa-mir-130b-5p ; hsa-mir-6728-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-5088-3p ; hsa-mir-6875-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-1224-3p ; hsa-mir-532-3p ; hsa-mir-4281 ; hsa-mir-6774-5p ; hsa-mir-635 ; hsa-mir-101-3p ; hsa-mir-2681-5p ; hsa-mir-374a-3p ; hsa-mir-4328 ; hsa-mir-511-5p ; hsa-mir-582-5p ; hsa-mir-6830-3p
Nearest miRNA
hsa-mir-1181/Upstream/338484; hsa-let-7e/Downstream/43526;
Nearest TSS
ENST00000633603/Upstream/2239; ENST00000585869/Downstream/28607;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/2538, chr19-CpG: 34/Downstream/2551
Upstream sequence
GCTCACCACCTCCAGCCGGTAGGTTCCAGGCCCCGGCCGCCTCCGCCCCAGCTGCAGGGAGCTGACGCCACGGAGGTGATGCATGCGAAAGAAACCTTGC
Downstream sequence
GGACTTAAAACCACGAGAATAAATAGGTTCGTGTATCAAGAACAAGCTAGGGATTTCACCAGCTAAATAGGACTGAAAAAATTCTCAAGACAAGAGCAAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate