Basic Information
VIS ID
TVIS20001681
Fusion event
HPV-LOC105373739 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr2
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
172766362/171909852 (Hg38)
End
172766362/171909852 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
LOC105373739
Nearest miRNA
hsa-mir-128-1/Upstream/3326834; hsa-mir-10b/Downstream/3257781;
Nearest TSS
ENST00000437798/Upstream/15600; ENST00000460481/Downstream/12596;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/221672, chr2-CpG: 56/Downstream/12371
Upstream sequence
gaagttctctgttatctctttgaataaactttatactcctctctctctctgcctcctcttgaaggtgaataactcttagatttgctattttgaggctatt
Downstream sequence
TGGGGGCTGGTTATTGTTTTTCAAAGATTTAACACTATAGTCTTGCAAAGAAGCAGACTAAACAGAGCATGATCCCTCAGTTCCTCCCTTTTCCATTAAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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