Basic Information
VIS ID
TVIS20001700
Fusion event
HPV-RASSF2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr20
Cytoband
p13
Reference genome
GRCh37/hg19
Start
4800738/4820092 (Hg38)
End
4800738/4820092 (Hg38)
Location type
Intronic
Target gene
RASSF2
miRNAs that regulate target gene
hsa-mir-429 ; hsa-mir-200a-3p ; hsa-mir-200c-3p ; hsa-mir-141-3p ; hsa-mir-124-3p ; hsa-mir-200b-3p ; hsa-mir-19b-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-942-5p ; hsa-mir-4480 ; hsa-mir-1227-3p ; hsa-mir-5589-3p ; hsa-mir-455-5p ; hsa-mir-4443 ; hsa-mir-6515-5p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-3667-3p ; hsa-mir-3121-5p ; hsa-mir-3613-3p ; hsa-mir-6888-3p ; hsa-mir-3191-5p ; hsa-mir-3120-5p ; hsa-mir-6768-5p ; hsa-mir-8485 ; hsa-mir-19a-3p ; hsa-mir-3165 ; hsa-mir-363-5p ; hsa-mir-3656 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-6745 ; hsa-mir-6849-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/902521; hsa-mir-1-1/Downstream/2551516;
Nearest TSS
ENST00000382410/Upstream/4969; ENST00000486875/Downstream/3553;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/58793, chr20-CpG: 94/Downstream/2275
Nearest cancer related gene
RASSF2(TSG, No orient, 0)
Upstream sequence
gtggatggatggatagatgagtggatgggtggctggatggataaatgaatgggtagatgggtggatgaaagggtaaattggtgggtggatggatgaatgg
Downstream sequence
CCCATTCACCAACCCCCGCCTCACACGGCCATGTGGTCCACAGTAACCAACAAGCAGGCCAAATAAATGAAACCAGCCGTGAGACCTGTGGGAGCTCACT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate