Basic Information
VIS ID
TVIS20001710
Fusion event
HPV-TPD52L2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr20
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
62509654/63878301 (Hg38)
End
62509654/63878301 (Hg38)
Location type
Intronic
Target gene
TPD52L2
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-93-3p ; hsa-mir-29b-3p ; hsa-let-7d-5p ; hsa-let-7b-5p ; hsa-mir-580-3p ; hsa-mir-920 ; hsa-mir-6726-5p ; hsa-mir-5591-5p ; hsa-mir-4300 ; hsa-mir-657 ; hsa-mir-558 ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-22-3p ; hsa-mir-6858-3p ; hsa-mir-5197-3p ; hsa-mir-1237-3p ; hsa-mir-1248 ; hsa-mir-211-3p ; hsa-mir-3173-3p ; hsa-mir-3182 ; hsa-mir-3185 ; hsa-mir-4270 ; hsa-mir-4441 ; hsa-mir-4533 ; hsa-mir-4677-3p ; hsa-mir-4679 ; hsa-mir-4747-5p ; hsa-mir-5196-5p ; hsa-mir-5702 ; hsa-mir-6754-5p ; hsa-mir-6868-3p ; hsa-mir-6891-5p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-937-5p ; hsa-mir-9500
Nearest miRNA
hsa-mir-1-1/Upstream/591435; hsa-mir-1914/Downstream/41148;
Nearest TSS
ENST00000382410/Upstream/13007; ENST00000474176/Downstream/8581;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/12458, chr20-CpG: 113/Downstream/16142
Upstream sequence
tcattaaagggctcagctgctatttgcttccccatggttgccatgcaagagtgcagggccagtaagcccaggtttgggttttacttgaaattatgtgatg
Downstream sequence
ATGTCTGAATGCGAGAGCAGCTGTGTTCTGCGAGTGGTGAAACAATTGCCTGTTGCATTCTATTTATAGGCAGAGGTAACTAAAAACCTCAGTGCTGAGA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate