Basic Information
VIS ID
TVIS20001713
Fusion event
HPV-chr21:q21.2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr21
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
25171440/23799123 (Hg38)
End
25171440/23799123 (Hg38)
Nearest miRNA
hsa-let-7c/Upstream/719731; hsa-mir-155/Downstream/1774857;
Nearest TSS
ENST00000624081/Upstream/321482; ENST00000415269/Downstream/91418;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/2800878, chr21-CpG: 28/Downstream/1562671
Upstream sequence
GGTTGTTAACCAACAGTTTGAATTTCTTCGCATCACTCTTACCCTGAAACTAATGCCCATGGGAGAAACATCATGTCATGTGGACTTGAGTCCCAGAGTC
Downstream sequence
ACACAAAGAGGTAGATAAAAATGCAAAGAATGTCCAAGCAGATCTGAGAGCAAAAGGAAGAGGGACATGGCAGAAGCAGTCACAATATTGACAACTCTGT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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