Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene42143481420629594214345342037587420420744206091942065340420559864205890442047097420490374207970142081487420514684205189842076035420763014205193242052081420863514208650042089351420895004207799242078125420660894206614842090534
Basic Information
VIS ID
TVIS20001721
Fusion event
HPV-UMODL1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
43510644/42090534 (Hg38)
End
43510644/42090534 (Hg38)
Location type
Intronic
Target gene
UMODL1
Nearest miRNA
hsa-let-7c/Upstream/343693; hsa-mir-5692b/Downstream/860394;
Nearest TSS
ENST00000624081/Upstream/5231; ENST00000475047/Downstream/20863;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/79154, chr21-CpG: 18/Downstream/15926
Upstream sequence
GAAGGTAATGGCTAGGCTCTCTCAGATGGCATGGGAATGGCTTAAttcctgtttgccccgggaatactcaccagcagtgcttacagctgcagcattcacc
Downstream sequence
ccgagataactctgccatgaaatatcttgcttttattattattttcgcatcactgtggtatattgactttggaaacagaggacacaattctacttatagc
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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