Basic Information
VIS ID
TVIS20001730
Fusion event
HPV-CHL1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr3
Cytoband
p26.3
Reference genome
GRCh37/hg19
Start
273814/232131 (Hg38)
End
273814/232131 (Hg38)
Location type
Intronic
Target gene
CHL1
miRNAs that regulate target gene
hsa-mir-10a-5p ; hsa-mir-335-5p ; hsa-mir-132-3p ; hsa-mir-181a-5p ; hsa-mir-590-5p ; hsa-mir-182-5p
Nearest miRNA
hsa-let-7g/Downstream/5018046;
Nearest TSS
ENST00000440867/Upstream/14596; ENST00000461289/Downstream/87552;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/33808, chr3-CpG: 20/Downstream/76846
Nearest cancer related gene
CHL1(OG, No orient, 0)
Upstream sequence
tcccaaagtgctgggattaaaggtgtgaggcaccgtgcccggcTGAAACTCTTAAAAATGTTATCAAAAAAGAAACACTACCTTTAGTCCTGTTATTTAT
Downstream sequence
GAAGGTTTTGGTGTCTACCATTACTGACCTCACTGTGAGGAGGCACCGGAGAATCATGATCTCATTCTGTGTATTGGCATGTCATTACACATTATTAATT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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