Basic Information
VIS ID
TVIS20001751
Fusion event
HPV-PHLDB2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr3
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
111647078/111928231 (Hg38)
End
111647078/111928231 (Hg38)
Location type
Intronic
Target gene
PHLDB2
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-1-3p ; hsa-mir-432-5p ; hsa-mir-376a-5p ; hsa-mir-382-3p ; hsa-mir-29c-3p ; hsa-mir-148a-3p ; hsa-mir-148b-3p ; hsa-mir-152-3p ; hsa-mir-202-5p ; hsa-mir-298 ; hsa-mir-4709-3p
Nearest miRNA
hsa-let-7g/Upstream/2325334; hsa-mir-12124/Downstream/184570;
Nearest TSS
ENST00000440867/Upstream/16621; ENST00000491694/Downstream/11296;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/68339, chr3-CpG: 40/Downstream/50661
Upstream sequence
ggcctatgatgtgacagcacctctggctcagaaatcctgaggtctgggcccctagaaaggtcaccactcttcactcacgcagtttgtctttgtcaccacg
Downstream sequence
GGACTTTTATACTGTGAAGTAAAGGCATTAGGACCAAATATTTTAAGAATAGTTTTTGGTGGATCCTGTATTAATGTTCTATATATTCATTAGAAAAATC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate