Basic Information
VIS ID
TVIS20001762
Fusion event
HPV-PCOLCE2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr3
Cytoband
q23
Reference genome
GRCh37/hg19
Start
142570682/142851840 (Hg38)
End
142570682/142851840 (Hg38)
Location type
Intronic
Target gene
PCOLCE2
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-182-5p
Nearest miRNA
hsa-let-7g/Upstream/8413934; hsa-mir-1224/Downstream/8714036;
Nearest TSS
ENST00000440867/Upstream/3496; ENST00000479792/Downstream/36905;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/126704, chr3-CpG: 103/Downstream/36513
Upstream sequence
aaacattgtttttatagtggaaatcatgtgcactggaaatatatttttcttcttcaatacatcgctcttttttgctcagttgctctcagccctatcagaa
Downstream sequence
CTGACACTACGTAGACAATTCTGTTGACTCTCTCCTGTAGAGAGGTGTTGAAATTAACTACAGGACTTGGATGCTCATTCCCAATAAAATAAATCATTTG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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