Basic Information
VIS ID
TVIS20001782
Fusion event
HPV-SLC2A9 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
9799735/9798111 (Hg38)
End
9799735/9798111 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
SLC2A9
miRNAs that regulate target gene
hsa-mir-5691 ; hsa-mir-6805-3p ; hsa-mir-466 ; hsa-mir-6740-3p ; hsa-mir-4778-3p ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-1264 ; hsa-mir-4446-5p ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-188-3p ; hsa-mir-1224-3p ; hsa-mir-4307 ; hsa-mir-33a-3p
Nearest miRNA
hsa-mir-378d-1/Upstream/241795; hsa-mir-12113/Downstream/280500;
Nearest TSS
ENST00000502981/Upstream/16431; ENST00000504249/Downstream/28489;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/14775, chr4-CpG: 49/Downstream/220746
Upstream sequence
ccaggcacagtggctctctcctgtaatcccagaactgtgggaggccaaggcaggcagattatgaggtcaggagttcgagaccagcctggccaacatggtg
Downstream sequence
GTCAGGATGGGTCTGGTGCAACCAGGTGATCCAAGGGTTATAGGCACAGAGGAAAGTAACTGGAGCTCCCTTTGGGTACCACAGTAAACACTGGTGATGG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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