Basic Information
VIS ID
TVIS20001786
Fusion event
HPV-LOC105374510 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr4
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
18650710/18649087 (Hg38)
End
18650710/18649087 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LOC105374510
Nearest miRNA
hsa-mir-12113/Upstream/5021130; hsa-mir-12115/Downstream/1879188;
Nearest TSS
ENST00000502981/Upstream/159579; ENST00000511431/Downstream/806349;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/626437, chr4-CpG: 284/Downstream/1602566
Upstream sequence
cacctgtattaaaaatggcatcctgccatcagtcctgggtctgtgaaaatgtctgcagatgttcccagtgtctttccttcatagtgtctcatagcctctc
Downstream sequence
agcacagtgaaccaaaggaaaaatagataaatggaatcacatcaagttaaaaagcatctgtgcagaaagaaaacaatcaacaaagtgaagagacaaccca
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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