Basic Information
VIS ID
TVIS20001791
Fusion event
HPV-PDS5A integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr4
Cytoband
p14
Reference genome
GRCh37/hg19
Start
39969399/39967779 (Hg38)
End
39969399/39967779 (Hg38)
Location type
Intronic
Target gene
PDS5A
miRNAs that regulate target gene
hsa-mir-130b-5p ; hsa-mir-93-3p ; hsa-mir-615-3p ; hsa-mir-128-3p ; hsa-mir-125b-5p ; hsa-let-7b-5p ; hsa-mir-5003-3p ; hsa-mir-335-3p ; hsa-mir-5089-3p ; hsa-mir-2115-3p ; hsa-mir-140-3p ; hsa-mir-499b-3p ; hsa-mir-499a-3p ; hsa-mir-302f ; hsa-mir-4282 ; hsa-mir-340-5p ; hsa-mir-376a-3p ; hsa-mir-376b-3p ; hsa-mir-3124-3p ; hsa-mir-5009-3p ; hsa-mir-1306-5p ; hsa-mir-6885-3p ; hsa-mir-4503 ; hsa-mir-6792-5p ; hsa-mir-4804-3p ; hsa-mir-4720-3p ; hsa-mir-944
Nearest miRNA
hsa-mir-12113/Upstream/555805; hsa-mir-1243/Downstream/534261;
Nearest TSS
ENST00000502981/Upstream/39673; ENST00000515550/Downstream/9731;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/196090, chr4-CpG: 194/Downstream/8667
Upstream sequence
gaacaaagaactagccacaccttgctagacttgacctacagaactgtgatctaacaagctgacatttattttcagccattttgtttgtggtaacttgcta
Downstream sequence
aaaccccgtctctaactaaaaatacaaaaattagctgggtgtggtggcagaagcctgtagtcccagctactcaggaggctgagctgagattgcgccactg
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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