Basic Information
VIS ID
TVIS20001799
Fusion event
HPV-MAPK10 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr4
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
87339976/86418823 (Hg38)
End
87339976/86418823 (Hg38)
Location type
Intronic
Target gene
MAPK10
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-574-5p ; hsa-mir-5572 ; hsa-mir-4260 ; hsa-mir-450a-2-3p ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-6819-5p ; hsa-mir-6812-5p ; hsa-mir-6737-5p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6747-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-342-5p ; hsa-mir-5002-5p ; hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p ; hsa-mir-3152-3p ; hsa-mir-641 ; hsa-mir-3617-5p
Nearest miRNA
hsa-mir-12113/Upstream/696290; hsa-mir-1243/Downstream/123659;
Nearest TSS
ENST00000502981/Upstream/34594; ENST00000507902/Downstream/34223;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/943007, chr4-CpG: 77/Downstream/175207
Nearest cancer related gene
MAPK10(TSG, No orient, 0)
Upstream sequence
CTTTTTAAAATGGAGGATTTAACTCTACAGGGTTCCCTGTAGAAAATGATATATTTTATGAACTCTGTATAATTCCATGTATGTGCTCAGCTGGAATAGG
Downstream sequence
ggaatactactcagccataaaaaggaataaaataatggcatgtgcagcaacctggatggagttggagaccactattctaagtgaagtaactcaggaatgg
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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