Basic Information
VIS ID
TVIS20001854
Fusion event
HPV-HMMR integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr5
Cytoband
q34
Reference genome
GRCh37/hg19
Start
162895018/163468012 (Hg38)
End
162895018/163468012 (Hg38)
Location type
Intronic
Target gene
HMMR
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-98-5p ; hsa-mir-93-3p ; hsa-mir-106b-5p
Nearest miRNA
hsa-mir-10397/Upstream/2982562; hsa-mir-103a-1/Downstream/4697833;
Nearest TSS
ENST00000502646/Upstream/7352; ENST00000519719/Downstream/26022;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/7776, chr5-CpG: 58/Downstream/37436
Upstream sequence
agtttatggatggcagttccaaagggaatgaacaacattctgtttggaagtctgctgctttgatcaaagaaggtaaaaacagatcagcttgatggggtga
Downstream sequence
TTACAATTATATATGTGGATCAAATATTTATATCTATCCATCGTTCACAGtcttcctgtatgctaacttatgttaacacaacatagctagaggatttctt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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