Basic Information
VIS ID
TVIS20001879
Fusion event
HPV-ROS1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr6
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
117739096/117417933 (Hg38)
End
117739096/117417933 (Hg38)
Location type
Intronic
Target gene
ROS1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-33a-5p ; hsa-mir-300
Nearest miRNA
hsa-mir-10398/Upstream/10633713; hsa-mir-1202/Downstream/1651114;
Nearest TSS
ENST00000381078/Upstream/80593; ENST00000533950/Downstream/7922;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/146817, chr6-CpG: 113/Downstream/64401
Nearest cancer related gene
ROS1(OG, No orient, 0)
Upstream sequence
tcagtaaagctaaaaCattttttatttaattttaaaaattaaGTTCCTATATTTATTAGCAGCTCTCAAAGAGCATTAAAGGGAATCCAGTTCATAGCTA
Downstream sequence
ccataattttatgcatatgtctgtctctctggttttaagtatgcatctcaaaaaggttgagagtccttttaaacagagaccctatttttttcattgttaa
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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