Basic Information
VIS ID
TVIS20001890
Fusion event
HPV-MAD1L1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr7
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
2069003/2029368 (Hg38)
End
2069003/2029368 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
MAD1L1
miRNAs that regulate target gene
hsa-mir-149-5p ; hsa-mir-20a-5p
Nearest miRNA
hsa-mir-339/Upstream/185115; hsa-mir-10399/Downstream/228147;
Nearest TSS
ENST00000635602/Upstream/48577; ENST00000454650/Downstream/50645;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/8872, chr7-CpG: 24/Downstream/20590
Nearest cancer related gene
MAD1L1(TSG, No orient, 0)
Upstream sequence
TCATTTTCTGTTCATCCAGAGACATAAATTGCCTTATTAAAGTTTAAAAATGAGACAGAATGTTGCTGGATAGAAATAGAAGAACATGTTTGGAAAACAG
Downstream sequence
GGCGTGTGAGAATCGGGAAGGCAGGGctttgggggaggtggaggagccggcaggtgaacttgggagccctggtgacaccgtgttcccgaccgtggagctg
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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