Basic Information
VIS ID
TVIS20001923
Fusion event
HPV-TUSC3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr8
Cytoband
p22
Reference genome
GRCh37/hg19
Start
15497345/15639836 (Hg38)
End
15497345/15639836 (Hg38)
Location type
Intronic
Target gene
TUSC3
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-26b-5p ; hsa-mir-1229-3p ; hsa-mir-25-3p ; hsa-mir-181a-5p ; hsa-mir-30e-5p
Nearest miRNA
hsa-mir-124-1/Upstream/786326; hsa-mir-10400/Downstream/2041742;
Nearest TSS
ENST00000518652/Upstream/16756; ENST00000511342/Downstream/33927;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/99058, chr8-CpG: 46/Downstream/1361699
Upstream sequence
GAACTGACTTGGCAGCAGATGTGAGATGAGGGGCAAACAAATTCTCACCCCCACCAGTCTCCACATCCTACTCAGCCCCATAGCCACGTCTCCTCTGTCC
Downstream sequence
TAAAACCACTTCAGATATAGTCCTTTCTTGTGATAGGTTGTTGTCTTTGTCACCATAATACAGTGAACAAAATAATATTCTTTTTATTTATCAGAAGACA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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