Basic Information
VIS ID
TVIS20001928
Fusion event
HPV-ADRA1A integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr8
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
26670622/26813105 (Hg38)
End
26670622/26813105 (Hg38)
Location type
Intronic
Target gene
ADRA1A
miRNAs that regulate target gene
hsa-mir-484
Nearest miRNA
hsa-mir-124-1/Upstream/1467631; hsa-mir-10400/Downstream/235748;
Nearest TSS
ENST00000518652/Upstream/175575; ENST00000521869/Downstream/41469;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/233836, chr8-CpG: 202/Downstream/51020
Upstream sequence
tggtgagagagcaacccagtgggaagtgaccgaatcataggggtggttttctccatgctgttttcacgatagtgagtgagttctcccaagatccgatggt
Downstream sequence
TAATAAAAGACTACACTTGCATTAATAGTAAAACATACTAGGGAAAAGTTTTTCAGTTACAGTTTCAGAAAGTTGTTCAGTTGCTATGAGAGTGGAAACT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate