Basic Information
VIS ID
TVIS20001930
Fusion event
HPV-ADAM32 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr8
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
39092320/39234801 (Hg38)
End
39092320/39234801 (Hg38)
Location type
Intronic
Target gene
ADAM32
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-124-1/Upstream/9277453; hsa-mir-10400/Downstream/2036247;
Nearest TSS
ENST00000518652/Upstream/13866; ENST00000517416/Downstream/36074;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/126897, chr8-CpG: 30/Downstream/287905
Upstream sequence
TCTAGTGCATTATAGATCTAATAAAGTGCATTCTAGAAAATGCACTTTAGAAAATTAGAAATAAGATAACCGAAAGCAGTTCTGAATATAATGTTCTGTG
Downstream sequence
TAGAacacaacatccaaatagctcaagccagccagagataagaacttaaaggcatttctccttcctgggggactgggctctcaactttccccatgctttt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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