Basic Information
VIS ID
TVIS20001948
Fusion event
HPV-FAM92A integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
94739766/93727538 (Hg38)
End
94739766/93727538 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
FAM92A
miRNAs that regulate target gene
hsa-mir-708-5p
Nearest miRNA
hsa-mir-12123/Upstream/697699; hsa-mir-10400/Downstream/188484;
Nearest TSS
ENST00000518652/Upstream/1690; ENST00000517998/Downstream/5678;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/26421, chr8-CpG: 44/Downstream/13209
Upstream sequence
TGTATATTTTTGTTTGGTATATTTACTAAGTGCACTCTTTCAAAACTTATTCTATAACTTTATCAATTCATGTGAATTTTAGCTCAATTTTCAAAGTTCA
Downstream sequence
aaggggacggaatactgtcctgtatattgtgacgacatcaagcagatattagcatcccccgcctctacctacaacatgccagtagcacacataaacacac
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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