Basic Information
VIS ID
TVIS20001950
Fusion event
HPV-OXR1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr8
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
107730345/106718117 (Hg38)
End
107730345/106718117 (Hg38)
Location type
Intronic
Target gene
OXR1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-200b-3p ; hsa-mir-567 ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-4781-3p ; hsa-mir-144-3p ; hsa-mir-3144-3p ; hsa-mir-3915 ; hsa-mir-6730-3p ; hsa-mir-4689 ; hsa-mir-6858-5p ; hsa-mir-1224-5p ; hsa-mir-3928-3p ; hsa-mir-642b-3p ; hsa-mir-642a-3p ; hsa-mir-586 ; hsa-mir-875-5p
Nearest miRNA
hsa-mir-12123/Upstream/2233652; hsa-mir-10400/Downstream/5925376;
Nearest TSS
ENST00000518652/Upstream/11736; ENST00000521864/Downstream/7895;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/59754, chr8-CpG: 92/Downstream/1364510
Upstream sequence
TTCTAAGATGGGCCATGCGGGATCCCTGCCACACGGGTGTGGGGGCAGCGCGCTCCTCCCTGCCTCGGCTGCTGTGTGTGTTAGTCTTCATGTTTCCCCT
Downstream sequence
TTTAATCTTGTTTCAGAATTATTTTTTCCAGTACTTCAACTGTTTAACTTTATGAACTCTATTCAGATCTTATTCATATCAGTACCCTAAAATATGTTAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate