Basic Information
VIS ID
TVIS20001959
Fusion event
HPV-GLIS3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr9
Cytoband
p24.2
Reference genome
GRCh37/hg19
Start
3930405/3930405 (Hg38)
End
3930405/3930405 (Hg38)
Location type
Intronic
Target gene
GLIS3
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-203a-3p ; hsa-mir-539-5p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-2355-3p ; hsa-mir-7159-3p ; hsa-mir-4482-3p ; hsa-mir-3679-3p ; hsa-mir-676-3p ; hsa-mir-431-5p ; hsa-mir-6852-3p ; hsa-mir-3909 ; hsa-mir-138-2-3p ; hsa-mir-3655 ; hsa-mir-3667-3p ; hsa-mir-6734-3p
Nearest miRNA
hsa-mir-1302-9/Upstream/3900124; hsa-let-7a-1/Downstream/919892;
Nearest TSS
ENST00000422679/Upstream/31763; ENST00000440674/Downstream/6784;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/403460, chr9-CpG: 69/Downstream/187420
Upstream sequence
ggacccagtcaaaggggagcccccacacatggttgaactttacctccaggaacttgacaaggttctcacagtaaatatcaaagaaaaatacccttgtgct
Downstream sequence
ccatgttggccaggctggtctcgaactcctgacctcaagtgatctgcctgcctcggcctcccaaagtgctgggaGTTGttttgagaccaggtctcacttt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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