Basic Information
VIS ID
TVIS20001977
Fusion event
HPV-ASTN2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr9
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
120024451/117262172 (Hg38)
End
120024451/117262172 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA9E ; FRA9B
Target gene
ASTN2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-526b-5p ; hsa-mir-1253 ; hsa-mir-591 ; hsa-mir-6761-5p ; hsa-mir-5571-5p ; hsa-mir-6880-5p ; hsa-mir-8085 ; hsa-mir-6746-5p ; hsa-mir-6731-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-765 ; hsa-mir-6077 ; hsa-mir-766-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-6760-5p ; hsa-mir-4419a ; hsa-mir-4779 ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-6770-5p ; hsa-mir-124-5p ; hsa-mir-6867-5p ; hsa-mir-5195-5p ; hsa-mir-8485 ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-6071 ; hsa-mir-6828-3p ; hsa-mir-3152-3p ; hsa-mir-1251-3p
Nearest miRNA
hsa-let-7a-1/Upstream/3052643; hsa-mir-12126/Downstream/2982807;
Nearest TSS
ENST00000422679/Upstream/47619; ENST00000450938/Downstream/152867;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/574684, chr9-CpG: 163/Downstream/150803
Upstream sequence
TGAGAGagtggtaaaaagcacagaatctggaaccagactgtatcttagctgggtcacttactatgtaacttagggaaagcttcctagtctctctgtgcct
Downstream sequence
gtggcgtgtgcctgtagtcccagctactctataggctaggacaggaggatcacttgagcccaggggtcgaggctgcagtgagccaggattgtgccactgg
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate