Basic Information
VIS ID
TVIS20001996
Fusion event
HPV-KDM6A integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chrX
Cytoband
p11.3
Reference genome
GRCh37/hg19
Start
44964432/45105187 (Hg38)
End
44964432/45105187 (Hg38)
Location type
Intronic
Target gene
KDM6A
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-6509-5p ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-1224-5p ; hsa-mir-3915 ; hsa-mir-526b-5p ; hsa-mir-3605-5p ; hsa-mir-3679-5p ; hsa-mir-1185-5p ; hsa-mir-6719-3p ; hsa-mir-4526 ; hsa-mir-3660 ; hsa-mir-6730-3p
Nearest miRNA
hsa-mir-1587/Upstream/5267574; hsa-let-7f-2/Downstream/640970;
Nearest TSS
ENST00000429181/Upstream/14370; ENST00000479423/Downstream/1753;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/231080, chrX-CpG: 20/Downstream/52545
Nearest cancer related gene
KDM6A(TSG, No orient, 0)
Upstream sequence
atgaaaaaaagctgtaatggccactaaattcagtataagtaaagagtgggggatggtggccggagaaaaaagaatcctgctataggctacagtcagatgt
Downstream sequence
AAGCTTGAGATTTTCTTTTAAAAACtcatagctcaaccacttaaatagctttatgacattagacaaacttaacttctctgcgctcctttttccccatttg
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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