Basic Information
VIS ID
TVIS20002010
Fusion event
HPV-COP1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr1
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
176030974/176061838 (Hg38)
End
176030974/176061838 (Hg38)
Location type
Intronic
Target gene
COP1
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-1180-3p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/93359; hsa-mir-1182/Downstream/967525;
Nearest TSS
ENST00000473358/Upstream/44561; ENST00000456125/Downstream/19418;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/462166, chr1-CpG: 108/Downstream/144737
Nearest cancer related gene
COP1(TSG, No orient, 0)
Upstream sequence
aatgaataaacaagccatagtcgtagagaaatatttgcaaatcatatgcctgataaagtacttgtatccacaatatataaagaactcttaataggaagaa
Downstream sequence
agcaaacacccacattttttaatggacaaactatttgaacagacacttcaccaataaaggaatatagatgccaaataagtacatgaagatgctcagcatc
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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