Basic Information
VIS ID
TVIS20002026
Fusion event
HPV-CLMN integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr14
Cytoband
q32.13
Reference genome
GRCh37/hg19
Start
95770259/95303922 (Hg38)
End
95770259/95303922 (Hg38)
Location type
Intronic
Target gene
CLMN
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4776-3p ; hsa-mir-192-3p ; hsa-mir-4480 ; hsa-mir-4756-3p ; hsa-mir-500b-3p ; hsa-mir-1912 ; hsa-mir-1295b-5p ; hsa-mir-6756-3p ; hsa-mir-5096 ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-4320 ; hsa-mir-6839-5p ; hsa-mir-378j ; hsa-mir-7113-3p ; hsa-mir-3667-3p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-4308
Nearest miRNA
hsa-mir-1260a/Upstream/165936; hsa-mir-1185-1/Downstream/4805497;
Nearest TSS
ENST00000550708/Upstream/7679; ENST00000554522/Downstream/3851;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/146039, chr14-CpG: 79/Downstream/15493
Upstream sequence
gtcttccagttccctttgtggcagctgttccacctggctccatctagccagccatcttgcctcaggagccccctGATTGATTTTTAAGTGCCTTCTATAT
Downstream sequence
CATTACATATTTAGATAataaaccctcaacgatggcaagaacagaagaaggggagacagcaatacaattctaggtggtagcaagaaggaccagtggtcac
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate