Basic Information
VIS ID
TVIS20002028
Fusion event
HPV-VPS35L integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr16
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
19606392/19595070 (Hg38)
End
19606392/19595070 (Hg38)
Location type
Intronic
Target gene
VPS35L
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-30a-5p ; hsa-mir-1180-3p
Nearest miRNA
hsa-mir-1225/Upstream/1100494; hsa-mir-11401/Downstream/1910979;
Nearest TSS
ENST00000527434/Upstream/3247; ENST00000540240/Downstream/6533;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/39004, chr16-CpG: 84/Downstream/122802
Upstream sequence
TTTCCCTCCCTAGACTAGATTTCTAATCTTGATGCAGTGAGCAAAGGGCGAGGTTTATATTGTTCTTACCTGAGCCAAAGGACCCATAAAAAATAGAGTG
Downstream sequence
cccgggagaggggcagaaactgacatggtcagagatcatggtggccttgggggccactgggaggacttgggctttgactctgactctgaggacaggaggg
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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