Basic Information
VIS ID
TVIS20002033
Fusion event
HPV-CAMKMT integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
44685983/44458844 (Hg38)
End
44685983/44458844 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
CAMKMT
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-1301/Upstream/8987358; hsa-mir-10b/Downstream/2918831;
Nearest TSS
ENST00000437798/Upstream/86096; ENST00000477830/Downstream/217750;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/96625, chr2-CpG: 19/Downstream/309681
Upstream sequence
tgtatttcctgaatctgaacgttggcctgccttgctagattggggaagttctcctggataatatcctgcacagtgttttccaatttggttccattctccc
Downstream sequence
GTAATACGAGGTTTCTAAAGGCCATACGTAACTGTGTACATAAAGAGGAAAGCTACTTGGGATAGAAGGACTCTCAGATTGGGTTTTAACTTCTCAAGTA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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