Basic Information
VIS ID
TVIS20002035
Fusion event
HPV-ANXA4 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr2
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
69927573/69700441 (Hg38)
End
69927573/69700441 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
ANXA4
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-8061 ; hsa-mir-4760-5p ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-3134 ; hsa-mir-1246 ; hsa-mir-4320
Nearest miRNA
hsa-mir-1301/Upstream/596686; hsa-mir-10b/Downstream/552477;
Nearest TSS
ENST00000437798/Upstream/26092; ENST00000484219/Downstream/13406;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/55857, chr2-CpG: 88/Downstream/41176
Upstream sequence
ggaggcactcagccttaagatggctagtttgaataatttcagtgggctctgatgcataaggatgtccctagttgtttggtacttggccttagggtaatta
Downstream sequence
TAAAAAGTCTTACTATCACTGCCACCATCCGTACTCTTCTCACTATTAACAATGTATTCATGACTGCAGAAAAGTATCTTACAATTATATAGAAATGACT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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