Basic Information
VIS ID
TVIS20002072
Fusion event
HPV-DPYD integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr1
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
97983038/97517482 (Hg38)
End
97983038/97517482 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1M
Target gene
DPYD
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-302b-3p ; hsa-mir-494-5p
Nearest miRNA
hsa-mir-101-1/Upstream/2973703; hsa-mir-11399/Downstream/527760;
Nearest TSS
ENST00000473358/Upstream/252036; ENST00000431362/Downstream/204172;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/795219, chr1-CpG: 47/Downstream/403151
Upstream sequence
GTCGAGCCATTAAGAAAGAACACAGTGTAATAAAATAGAAAAGTTAGCCCATGAAACACTCCACCTTCTCCCGTCCACATCACAAACATTTCCTAAGGCA
Downstream sequence
ATGGAGTTAAAGAAATGAAACAAATCAATAGTTTTGTTCAGAAGACATACTTTGTAACTGAAATTTCTTCAACGTTATTTATTAAGCACCTCCTACATAC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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