Basic Information
VIS ID
TVIS20002074
Fusion event
HPV-CHD1L integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr1
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
146733334/147261677 (Hg38)
End
146733334/147261677 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
CHD1L
miRNAs that regulate target gene
hsa-mir-320a
Nearest miRNA
hsa-mir-101-1/Upstream/1411032; hsa-mir-1182/Downstream/1072802;
Nearest TSS
ENST00000473358/Upstream/18627; ENST00000485113/Downstream/9227;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/18049, chr1-CpG: 81/Downstream/337779
Nearest cancer related gene
CHD1L(OG, No orient, 0)
Upstream sequence
tccagcctgagcaacagagtgagatcctgtctcaaaaaccaaacaaaaTGTAAATAGTGttcatggagttcctaccgtgggctgggctctctgcaagaca
Downstream sequence
cagcatccatgcctgggtccccaccgagcttggggcaggggaggaggcaggatgcaggccttcaacaaccagttgcaagacagggtggcagtgcagaaat
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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